PENGARUH KONSENTRASI N-METHYL-2-PYRROLIDONE (NMP) DI MEDIA GELATINISASI PADA PERFORMA MEMBRAN POLYETHERSULFONE (PES) MOLECULAR WEIGHT 5200
Abstract
This research presents the development of water-permeable dialysis membranes that are suitable for an implantable microdialysis system without dialysis fluid. This microdialysis system integrates microfilter and nanoporous filtering membrane made of polyethersulfone (PES). The simplicity of this microfilter device is important to be applied in the implantable dialysis system, in which current Wearable Artificial Kidney (WAK) emerges the problems on the size and weight of the pumps and storage tanks for the dialysis fluid. Therefore, this research focuses on developing membranes for hemofiltration that doesn’t require dialysis fluid but its permeability is high. The researcher has conducted two modifications to increase the permeability of PES membranes, that are on casting solution and gelatinization media. The concentration ratio used on casting solution refers to previous research from To et al. (2015). While on gelatinization media, the researcher used the influence of n-methyl-2-pyrrolidone (NMP) additional amout on the varying gelatinization media. The result revealed that the gelatinization of 7 % NMP give the biggest influence on PES membranes permeability. The result of the performance experiment by examining the diffusion shows that the water flux of 740,7 L/m2.hour.mmHg and the diffusion coefficient reaches 1,E-01 (0,100) mm2/s. The morphology monitoring with Scanning Electron Microscopy (SEM) shows that the pores membrane is larger and the pores distribution is spread evenly, in which it means that the PES membranes porosity is increased. While the monitoring of PES membranes water contact angle that submerged in 7 % of NMP shows the smaller value, that is 43 , so it can be categorized that PES membranes are hydrophilic. Hence, by analyzing the result of performance and morphology characteristic, it can be concluded that the gelatinization concentration of 7 % NMP can increase the permeability of PES membranes by modifying casting solution and gelatinization media