Customer loyalty will determine whether a customer will come back or not and whether they would recommend the Muhammadiyah Yogyakarta Hospital to others to use it or not. To maintain customer loyalty, it is necessary to do reassessments regarding Effect Feature Customer Relations Management and Trust. It is necessary to identify how the influence of CRM and trust proper order according to the customer a satisfied customer can become a loyal customer at Muhammadiyah Yogyakarta Hospital The type of research method is explanatory approach with Likert scale quesionaire as the data collection technique which allotted to fifty employees of the organization. Analysis of the data in this study using validity, reliability testing, and regression. The results of this study indicate that the Customer Relations Management Features positive effect on patient loyalty PKU Muhammadiyah Yogyakarta Hospital with regression coefficient of the influence of CRM features and customer loyalty is equal to 0.123 and a significance value of 0.000. Belief positive effect on patient loyalty PKU Muhammadiyah Yogyakarta Hospital was shown the regression coefficient of the influence of the trust and loyalty of consumers is equal to 0.297 and a significance value of 0.000. Features Customer Relations Management and confidence positive effect on patient loyalty PKU Muhammadiyah Yogyakarta Hospital shown calculated F value of 177.743 with pvalue value of 0.000. The results of the analysis of the coefficient of determination (R2) of 0.786, it means that 78.6% of CRM features and beliefs influence on consumer loyalty.