The complexity of patient’s problems cannot be handled by the medical profession, but must involve the various health professions. The practice of collaboration is necessary for patient safety and increase the satisfaction and the creation of good quality health care. Interprofessional collaboration practice can be applied through Education (IPE). In the interprofessional approach, one thing that is needed is the Shared-Decision Making (SDM). Purpose: The purpose of this study was to determine the relationship of preparedness in interprofessional Education (IPE) with the abilityof Shared-Decision Making (SDM). Methods: This study was a quantitative research. IPE is measured using Readiness for interprofessional Learning Readiness Scale (RIPLS) questionnaire, while the human resources capacity was measured using the Assessment of interprofessional Team Collaboration Scale (AITCS) questionnaire. This Research was conducted in December 2015 until April 2016 in Asri Medical Center. Respondents are consisted of 85 people who were students of co-assistent of medical, co-assistent of dentistry, co-ners and student of pharmaceutical study program. Results: There was no relationship between the readiness to interprofessional Education (IPE) with the ability Shared-Decision Making (SDM) to the students of the Faculty of Medicine and Health Sciences, University of Muhammadiyah Yogyakarta. It can be seen from the results of Chi-Square test, the obtained value of p = 0.160. Conclusion: There is no relationship between the readiness to interprofessional Education (IPE) with the ability Shared-Decision Making (SDM).