The purpose of this study is to examine the effect of the stock price, trading volume, liquidity, leverage, earnings per share and return the stock to the bid-ask spread Islamic stock. The population of this study is a company that register in the years 2014 to 2015 list of islamic securities. The technique of sampling in this study is using purposive sampling method which criteria that list in Indonesia stock exchange company, presenting in rupiah, and also have a complete data during study period until it gets 185 total sample of companies that list in Islamic securities. The method of analysis data is using multiple linear regression. The result of the study are showing that the stock price, trading volume, liquidity, leverage, earnings per share and stock returns simultaneously significant effect on the bid-ask spread of Islamic stocks. Variable stock price, earnings per share and return stock partially significant negative affect on the bid-ask spread of Islamic stocks. Trading the volume variable which partially significant positive effect on the bid-ask spread of Islamic stocks. While the variable of partial liquidity and leverage do not affect the bid-ask spread of Islamic stocks.