Diabetes Mellitus is a serious health problem in Indonesia, because the amount of patient is continuously rise. Diabetes mellitus will cause long-term complications if not handled properly, some of the complications that may arise include the disruption of retinopathy with potential blindness, nephropathy disorders that can lead to kidney failure. These conditions lead to diabetes mellitus have psychological disorders such as depression. Depression can be caused by biological factor, genetic factor and psychosocial factor, but it is also because of demographic factor, such as gender, age group, education level, occupation and marital status. These factors can influence each other. Therefore, research on the relationship between demographic factor with depression in diabetes mellitus’s patient in Gunungkidul DIY is very important to do. Method : This study is a non-experimental with cross sectional approach. As 36 diabetes mellitus patients are measured the depression score using a Beck Depression Inventory (BDI) questionnaire. Purposive sampling technique is used so that we got 36 patient as samples. Then the data will be analyzed using chi-square test. Results : From 36 sample, showed that 27,8% patient with diabetes mellitus patient are depressed. The result of normal/minimal is 72,2%, mild depression is 16,7%, moderate depression is 8,3%, and severe depression is 2,8%. The results of chi-square test showed that demographic factors (education level) is associated with depression, with p value= 0,04 (significant), where p<0,05, but the another demographic factor (gender; age group; occupation and marital status) is not associated with depression, with p value= 0,185; 0,520; 0,089; and 0,875 (not significant), where p> 0,05. Conclusion : The study shows that there is no significant relationship between demographic factor with depression in hypertension’s patient in Gunungkidul DIY, except the education level.