This study aims to determine the effects of Government Health and Education Expenditure, also Total Population on Human Development Index in the OIC member countries, case study of 19 sub-Saharan African countries in 2010-2014. The analytical tool is used in this research is data panel. This study identified that Health Expenditure contributing to human development in the selected countries. Thus, it is showed that the countries concerned should articulate health policies that will ensure proper funding and adequate utilization of budgetary allocation to the health sector, especially the primary health care delivery system that is pro-poor oriented, since all countries in sub-Saharan region are included in Low Human Development category. In addition, Education Expenditure has positive and significant impact on Human Development Index. Sustainable development consists of persistent production, accumulation and optimal utilization of their human capital. Furthermore, the stock of human capital consists of the education, knowledge, skills and experience of people. Therefore, adequate funding as well as proper utilization of funds in the education system is required to ensure the contribution of the sector to human development. Nevertheless, Total Population has positive but insignificant effect on Human Development Index.