This study aims to analyze the influence of profitability, growth, Investment Opportunity Set (IOS) to firm value with leverage as intervening variable study on manufactured companies which are listed on the Indonesian Stock Exchange period 2010-2014. In this study, samples of 262 sample and 74 companies were selected using purposive sampling. Analysis tool used in this study is SPSS 16 and Eviews 7. Based on the analysis that have been made the result are profitability, growth, and Investment Opportunity Set has positive significant effect to firm value, profitability has positive but no significant effect on leverage, growth has positive significant on leverage, Investment Opportunity Set has negative no significant on leverage. Leverage could significant mediating profitability, growth, and investment opportunity set on firm value.