This study aimed to analyze the Influence of Asset Structure, Profitability, Liquidity, size and business risk on capital structure. Subjects in this study is manufacturing companies was listed in Indonesia Stock Exchange. This study using purposive sampling method. The analytical tool used was SPSS Statistics. Samples that I use in this research is manufacturing companies listed on the Stock Exchange in the period from 2012 to 2015. In this study, there are 32 manufacturing companies that fall into my criteria, it is companies that have earnings in the period of the study. Based on the analysis that has been done shows that the profitability and likuidity of significant negative effect on capital strucutre and asset structure, size and business risk no significant and negative effect on capital structure.