The purpose of this study was to examine and analyze the influenceof work family conflict, job stress, organizational commitment to employee performance. The object of research in this study is RS PKU Muhammadiyah Gamping. Data was collected through questionnaires filled out independently of the 80 respondents using purposive sampling method. Based on the analysis of data using Multiple Linier Regression by SPSS Version 23 program. Results from this study proves and gives the conclusion that: (1) work family conflict negative significant on employee performance (2) job stress no significant on employee performance (3) organizational commitment positive significant on employee performance.