| dc.contributor.author | DJATI, MUHAMMAD SASMITO | |
| dc.date.accessioned | 2017-09-06T06:01:35Z | |
| dc.date.available | 2017-09-06T06:01:35Z | |
| dc.date.issued | 2016-12-09 | |
| dc.identifier.isbn | 978-602-757-793-0 | |
| dc.identifier.uri | http://repository.umy.ac.id/handle/123456789/14341 | |
| dc.description | Herbal Medicine is one uniqueness medicinal approach, basic way of thinking
of traditional medical is human healthy by means of balance condition of human bodies.
Body’s human balance should be approach systemic, holistic, and material, as well as
immaterial domain. One case of complicated system in human is pregnancy, pregnant
women are one of higher risk population for Salmonella typhii infection. Typhoid fever
during pregnancy can cause decreasing immune system and imparity of the hormonal
system. Indonesia have a lot of herbal medicine, there are Elephantopus scaber (Tapak
Liman) and Sauropus androgynus (Katuk). Both can use as a herbal supplement for
pregnant women because they have functioned as an anti-in ammatory effect, antimicrobial
and stimulate reproduction hormone. The aim of this study was to investigate
the ef cacy of E. scaber and S. androgynus as a food supplement for modulating immune
and hormonal system in Pregnant mice with Salmonella typhii infection. Pregnant mice
were orally infected with S. typhii, at a concentration 107 CFU/mL. Extract of E. scaber
and S. androgynus were administered orally using formulation 100:0% (T3), 75:25%
(T4), 50:50% (T5), 25:75% (T6), and 0:100% (T7), with initial doses of 200 mg/kg body
weight (BW) E. scaber and 150 mg/kg BW S. androgynus. Lymphocyte cell was isolated
from bone marrow, spleen, and lymph node. Pregnant BALB/c mice serum was isolated
from the orbital vein. FACS analysis was done to measure the relative number of B220+
cell and CD4+IL2+ T cell. The hormonal level was analysis using ELISA assay. The data
were analyzed using one-way ANOVA, with signi cance level p<0.05, followed by a
Tukey test. The statistical analysis software used SPSS version 16.0. The result shows
that the combination leaves extract of E. scaber and S. androgynus have ef cacy to
modulated immune system such as B220+ in bone marrow and also lymph node, IL2,
and CD4 T cell. Beside, both leaves extract are also modulating hormonal system like
prolactin hormone in pregnant mice with S. typhi infection. | en_US |
| dc.description.abstract | Herbal Medicine is one uniqueness medicinal approach, basic way of thinking
of traditional medical is human healthy by means of balance condition of human bodies.
Body’s human balance should be approach systemic, holistic, and material, as well as
immaterial domain. One case of complicated system in human is pregnancy, pregnant
women are one of higher risk population for Salmonella typhii infection. Typhoid fever
during pregnancy can cause decreasing immune system and imparity of the hormonal
system. Indonesia have a lot of herbal medicine, there are Elephantopus scaber (Tapak
Liman) and Sauropus androgynus (Katuk). Both can use as a herbal supplement for
pregnant women because they have functioned as an anti-in ammatory effect, antimicrobial
and stimulate reproduction hormone. The aim of this study was to investigate
the ef cacy of E. scaber and S. androgynus as a food supplement for modulating immune
and hormonal system in Pregnant mice with Salmonella typhii infection. Pregnant mice
were orally infected with S. typhii, at a concentration 107 CFU/mL. Extract of E. scaber
and S. androgynus were administered orally using formulation 100:0% (T3), 75:25%
(T4), 50:50% (T5), 25:75% (T6), and 0:100% (T7), with initial doses of 200 mg/kg body
weight (BW) E. scaber and 150 mg/kg BW S. androgynus. Lymphocyte cell was isolated
from bone marrow, spleen, and lymph node. Pregnant BALB/c mice serum was isolated
from the orbital vein. FACS analysis was done to measure the relative number of B220+
cell and CD4+IL2+ T cell. The hormonal level was analysis using ELISA assay. The data
were analyzed using one-way ANOVA, with signi cance level p<0.05, followed by a
Tukey test. The statistical analysis software used SPSS version 16.0. The result shows
that the combination leaves extract of E. scaber and S. androgynus have ef cacy to
modulated immune system such as B220+ in bone marrow and also lymph node, IL2,
and CD4 T cell. Beside, both leaves extract are also modulating hormonal system like
prolactin hormone in pregnant mice with S. typhi infection. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Departement of Biology, Faculty of Mathematic and Natural Sciences, Brawijaya
University Malang | en_US |
| dc.subject | SAUROPUS ANDROGYNOUS | en_US |
| dc.subject | ELEPHANTOPUS SCABER | en_US |
| dc.subject | SALMONELLA TYPHI | en_US |
| dc.title | HERBAL MEDICINE A HOLISTIC APPROACH; IN CASE OF FOOD SUPPLEMENT FORMULATION OF SAUROPUS ANDROGYNOUS AND ELEPHANTOPUS SCABER TO MODULATE IMMUNE AND HORMONAL SYSTEM IN PREGNANT SALMONELLA TYPHI INFECTED MICE | en_US |
| dc.type | Book | en_US |
