This study aims to analyze the effect of FDR, CAR, BOPO and NPF on Profitability of Islamic banks in Indonesia. The subject of this research is 11 Sharia Commercial Banks in Indonesia. In this study the sample amounted to 55 financial reports from 11 Islamic banks in Indonesia. In determining the suitable samples used purposive sampling method. The method used in this research is Panel data analysis, the method used in panel data are Common Effect, Fixed Effect and Random Effect. The test used to determine the method that will be used in this research is Chow Test and Hausman Test. Based on the analysis that has been done obtained the result that the Financial to Deposit Ratio does not affect the profitability, Capital Adequacy Ratio does not positively affect the profitability of the Sharia Commercial Bank in Indonesia, Oprasional Oprasional Oprasional Costs affect the profitability at Sharia Commercial Bank in Indonesia, and, Non Performing Finance Negative Influence on Profitability existing in Sharia Islamic Bank in Indonesia that exist in Indonesia.