Background: In these past few years, automotive industrials are developed rapidly in Indonesia, which also given an impact on the employment of the workers. In the other hand, automotive industrials produce many pollutans such as benzene, lead, and carbon monoxide that can affect healthiness (of the human body) especially on the count of platelets. Thrombocyte consist of platelet items that works to prevent blood lost by clotting which can close the wound. Automotive workers (mechanic workers) are having higher risk to exposed by more pollutans than the workers who work inside the building such as cleaning service. This research is needed to perceive the difference of the platelet count between workers whos exposed to the pollutans and workers whos not exposed to pollutans. Purpose: To to perceive the difference of the platelet count between workers whos exposed to the pollutans and workers whos not exposed to pollutans. Methods: This research is an analytic observational study with cross sectional design. This research was done by collected blood samples of workers whos exposed to pollutans (mechanic woorkers) at Bantul and workers whos not exposed to pollutans at Universitas Muhammadiyah Yogyakarta in the range of February until May in 2017. Platelet levels were examined from the blood sample in Balai Laboratorium Yogyakarta. Total samples is 40 samples consisted of 20 workers whos exposed to pollutans and 20 workers whos exposed to pollutans. Data was analyzed by Independent Sample T Test. Results and Discussion: The average value of platelet count of workers whos exposed to pollutans is 269,35 and workers whos not exposed to pollutans is 269,30. So, it conclude that average value of platelet count of workers whos exposed to pollutans is lower than workers whos not exposed to pollutans. There is no meaningful difference of platelet count between workers whos exposed to pollutans and workers whos not exposed to pollutans. It can be proven from the result of Independent Sample T Test which showed p > 0,05 (p = 0,889). Conclusion: This research concluded that there is no difference of platelet count between workers whos exposed to pollutans and workers whos not exposed to pollutans.