Background: The public knowledge about DHF is something that known by community including sympthoms, signs, causes, vector, eradication and prevention of DHF. The public knowledge about DHF was proved to influence the case of DHF. With the adecuate knowledge about DHF, the community will be able to reduce the case of DHF through vector control and reduce the mortality caused by DHF through awareness the signs that appear in their family even theirselves. This study is needed to evaluate the stage of public knowledge about DHF between high endemic area and low endemic area in Sleman Distric of Yogyakarta. Method: The research design of this study is Cross Sectional Study. It is conducted on 696 people that enter to inclusion characteristic. The Sample including 338 people in high endemic area (Gamping Subdistrict) and 358 people in low endemic area (Moyudan Subdistrict). Respondent was given a questioner which contain self data, occupation, education, history of DHF, and several question around the knowledge about DHF. Result: The result from the average score of knowledge in high endemic area (Gamping Subdistrict)=65,62 and the average score of knowledge in low endemic area (Moyudan Subdistrict)=64,36. The analyzes by using Mann-Whitney Test shows that the average scores in both endemic areas are not significant different (p=0,274). Conclusion: There is no differences from the stages of public knowledge about DHF between high endemic area and low endemic area in Sleman District of Yogyakarta