Background: Asthma is a chronic inflammatory disease of the respiratory tract with a high prevalence in Yogyakarta, Indonesia. Improving the quality of life is important done by the asthma itself. Health promotion on asthma and breathing exercises Buteyko has benefits to improve the quality of life of asthma sufferers. This study aims to determine the effect of health promotion on asthma on the quality of life of people with asthma. Method: Quasi ekperimental with pre-test and post-test with control group design performed on 40 patients of outpatient asthma and inpatient at PKU Muhammadiyah Gamping Hospital in February until April 2017. Respondents consisted of 20 respondents as intrvensi group and 20 respondents as control group. Result: Wilcoxon test results of quality of life of 4 domains (symptoms, activity limitations, emotional function, environmental stimuli) intervention group successively got value P <0,001. The mean quality of life of the 4 domains of the intervention group experienced a significant increase after the intervention was given. Results of Wilcoxon test of quality of life analysis 4 domains of control group were obtained P = 0.005, P = 0.005, P = 0.005, P = 0.003. The mean of quality of life of 4 control group domains experienced an insignificant increase in the domain of symptoms, activity limitations, emotional functioning, and environmental stimuli, and decreased in the domain of emotional function. Result of Mann-Whitney test analysis of pre-test group intervention and quality of life control of 4 domains obtained value P = 0.012, P = 0.012, P = 0.069, P = 0.011. Then in the post-test group intervention and control successively obtained value P = <0.001. Conclusion: The health promotion of asthma has a significant effect on the quality of life of asthmatics.