The purpose of this reseach is to examine the effect of profitability, growth opportunity, size, and capital structure on firm value. The object is manufacturing companies that listed in Indonesia Stock Exchange (BEI) in period 2012-2106. This research using purposive sampling method as technique sampling with the number of samples acquired is 25 companies and in total 121 samples. The data analysis technique of this study using multiple regression analysis with E-Views 7 program. The result of this research that profitability, size, and capital structure have positive significant influence on firm vlaue. Meanwhile, growth opportunity have not significant influence on firm value.