The objective of this research is to examine The effect of profitability, liquidity, capital structure, Institutional ownership and Corporate Social Responsibility (CSR) to the firm value by Manufacturing Company listed in Indonesian Stock Exchange in 2012-2016. The variable Profitability as measured by Return On Equity (ROE), Liquidity as measured by Current Ratio (CR), Capital Structure as measured by Debt to Equity Ratio (DER), and Institutional ownershipand Corporate Social Responsibility (CSR) and Firm Value are measured by using Tobins'Q as the dependent variable. Based on Purposive Sampling technique, it got 48 companies with 225 samples by Manufacturing Company listed in Indonesian Stock Exchange in 2012-2016. The method it got analysis of this research was Multiple Linear Regression Analysis. The result of research showed Profitability has significant positive effect on Firm Value, Liquidity has not significant effect on Firm Value, Capital Structure has significant positive effect on Firm Value, Institutional Impairment has not significant effect on Firm Value and Corporate Social Responsibility (CSR) has significant positive effect on Firm Value