Background: Hospitals have function for healing and maintaining health. This function must be carried out in a well integrated manner as a way to improve the patient safety quality. The problems experienced by most patients are related to the patient safety quality so that many patients or family members complain that the services provided are less than optimal. Human resources in an institution are important aspects that can determine whether an organization is effective or not. Health workers who do not have the competence and professionalism will not be able to provide high quality services and ensure safe health practices Reserach Objective: To analyzed the competence and professionalism of medical personnel influence the patient safety in private hospital of Central Java. Method: Quantitative research with cross sectional approach. The population was all medical personnel of Central Java Private Hospital employees in 2018. The sampling technique was total sampling as many 53 people. Data collection techniques used questionnaires. Data analysis used was multiple regression analysis. Result: Competence had positive and significant influence against the safety patients quality. Professional human resources had positive and significant influence against the safety patients quality. Competence and professional human resources had positive and significant influence against the safety patients quality with the amount of contribution as much 60,6%. Conclusion: Competence and professional human resources influence the safety patients quality in Central Java Private Hospital. Keywords: Competence, professional human resources, safety patients quality