Background: There are many hospitals now in Indonesia although the standards are still very minimal. Therefore, the Hospital Accreditation Commission (KARS) was formed which functions to accredit hospitals throughout Indonesia. With the existence of this KARS all hospitals now must follow the standards that have been set. One of the standards set by KARS is about Key Performance Indicators (KPI), this KPI is prepared based on the indicator data of each unit in the hospital. At present, there are already KPIs in the Surakarta Regional General Hospital, but they are still not perfect in terms of making and implementing them. This is why researchers made a thesis about the preparation of KPI at the Surakarta City Regional General Hospital, with the hope that researcher can help hospitals in evaluating existing KPIs and also indirectly assisting in the hospital accreditation process. Objective: The objective of study is to find the best Key Performance Indicators that can be used in RSUD Kota Surakarta.. Method: This type of research is a qualitative study with a case study research design. In analyzing this research, the authors used secondary data in the form of hospital data. The subject of the study is the profile of public hospital in the city of Surakarta, the object is Key Performance Indicator. The collected data is reviewed and identified with the committee with meetings and discussions. Result and Discussion: The unit indicator data that has been collected from all of the units in hospital, inc outpatient units, emergency unit, inpatient units, supporting units are calculated using a grading matrix and then concludes that the area used is the inpatient area. The results obtained by researchers for the preparation of KPIs show that there are differences with the KPIs that are owned by the RS at this time, which is in accordance with the hypothesis of the researchers. This happens because of several things, namely: Urgent time ahead of Accreditation of Hospital so that it cannot be maximized in working on KPI formation, the committee has not been formed at first and after forming the Committee itself the competence is still lacking because there is no comprehensive training on KPI, the person in charge of xx each unit has not received a specific socialization about KPI, the absence of data of each unit. Conclusion: KPI in Clinical Area at RSUD Kota Surakarta are 1.Patient Assessment - Number of incomplete initial 24-hour assessments at the Inpatient Unit, 2.Laboratory Services - Waiting time for results of Laboratory services <120 minutes, 3.Radiology Services - waiting time for standard photo thorax service ≤3 hours, 4.Surgical Procedure - Site marking location of the operation, 5.Use of antibiotics and other drugs - Aspirin use within the first 24 hours of hospital admission in patients with a diagnosis of AMI, 6.Medication error and near injury (KNC) - Percentage of medication error rates,7.Use of anesthesia and sedation - Use of anesthesia and sedation, 8.Use of blood and blood products - The incidence of transfusion reactions, 9.Completeness of medical record (MR) - Completeness of filling in RM files after 24 hours of hospitalization, 10.Infection prevention and control (PPI), surveillance and reporting - The percentage of compliance of health workers in doing hand hygiene with the 6 step method at 5 moments was hospitalized Keyword: KPI, case study, qualitative, Balanced scorecard, accreditation