The objectives of this research are: (1) to identify the factors underlying the implementation of the partnership program; (2) to identify potential and supporting capacity in the implementation of partnership program; (3) to describe the processes and steps taken in the implementation of the partnership program; and (4) to find out the effect of the partnership program on the quality of learning and teacher competence. This research uses qualitative-quantitative approach (mixed method) with sequential exploratory research model. This researchmodel in the early stages uses qualitative method then quantitative. Qualitative approach is using context evaluation method, input, process and product (CIPP). The next step uses a quantitative approach to determine the effect of a partnership program (sister school) on improving the quality of learning and teacher competence. Based on the analysis and discussion of the research, it can be concluded that the partnership program with the overseas school (sister school) in improving the quality of learning and teacher competence is basedon the vision of the school as a leading school and also based on the desire to maintain the existence in the community as branding as a favorite school. The sister school program is implemented by involving school elements that include: school committee, principal, teachers, educational staffs, students andstudents’ parents and the community. Teacher involvement as a subject in this program is very good with theirdirect involvement as participants who are sent or not by other teachers. The sister school program is also supported by the involvement of participation and cooperation network between Muhammadiyah schools. The process of implementation of sister school program is based on a Certificate of Agreement (CoA) with a partner school which contains agreements to cooperate in religious, educational, cultural, student exchange, teachers including exchange of learning materials and learning process, learning software, courses, documents, project results, culture, art, science, language, and school management. However, not all the points in the CoA are realized. The results shows that there is an influence between sister school program on improving the quality of learning and teacher competence in SD MuhammadiyahBodon. However, these influences have low significance. The low significance of the influence of sister school program on the quality of learning and teacher competence in SDMuhammadiyahBodonis due to factors in the absence of program achievement indicator that was determined. In addition, formally structured and programmed follow-up action plan is also not optimal yet. Keywords: program evaluation, school cooperation, sister school, quality of learning, teacher competence