Indonesia is a multiethnicity nation. At least 931 ethnic groups and 731 indigenous languages live in Indonesia. Some ethnic groups are major ethnic and another minor ethnic. Examples of the major ethnic group are Javanese, Sundanese, Madurese, Malays, Balinese, Minangkabau, Batak, Dayak, Bugis, and Chinese. The culture of Chinese as general and also in Indonesia is seen by many people has a big gap with Islamic teachings. Interactions between ethnicity will result in integration, but sometimes they bring conflicts too. Social interaction between Chinese and other ethnic groups is good in the City of Singkawang. A factor relates to that condition is Islam. It helps Chinese in Indonesia to integrate and blend into indigenous ethnic groups. Usually, a Muslim Chinese is seen as an indigenous people. There are few communities of Muslim Chinese in Indonesia. An individual of them faces many obstacles to embrace Islam. Therefore, it is interesting to study "Religious and Social Interaction of Chinese Muslims in Singkawang City”. It is studied using Interaction Theory as the basis for discussion. Research approach in the study is qualitative approach by observation, interview, and documentary. The participants of the study are 4 (four) Muslims Chinese. The result of the study is containing a moral and Islamic message that is valuable to be studied.