Background: Contact irritant dermatitis (DKI) is a non-immunologic inflammatory reaction to the skin due to contact with irritant ingredients. DKI can be suffered by everyone affeced by age, gender, types of job and history of previous skin disease. Purpose: To find out the relation between incidence of DKI with various risk factors in PKU Muhammadiyah Gamping Hospital of Yogyakarta. Methods: This study was an observational analytic study with cross-sectional study design. The study sampel was patient medical records with DKI at PKU Muhammadiyah Gamping Hospital of Yogyakarta period of September 2016 to September 2017 taken from medical rexords that meet the inclusion and exclusion criterias. Data analysis using chi-square test to test the relationship or influence of 2 nominal variables and measure the relationship strength between these variables, and logistic regression to test whether the possibility of DKI occuring can be predicted with age, gender, types of job and history of previous skin disease. Results: The bivariate analysis shows that there are no relations between age (p=0,163; OR=1,710; 95% CI 0,805-3,633), gender (p=0,258; OR=1,544; 95% CI 0,727-3,279) and types of job (p=0,081; OR=0,492; 95% CI 0,222-2,091) with incidence of contact irritant dermatitis. There is relation between history of previous skin disease (p=0,000; OR=5,695; 95% CI 2,714-11,950) with incidence of contact irritant dermatitis. Conclusion: History of previous skin disease can increase the risk of contact irritant dermatitis