This study aims to analyze the Effect of Entrepreneurship Education and Entrepreneurial Motivation on Entrepreneurial Intention with Self-Efficacy as an Intervening Variable at Muhammadiyah University of Yogyakarta. The subjects in this study were students of the Faculty of Economics and Business Management. The sample used amounted to 200 respondents selected by purposive sampling method. The analytical tool used is Structural Equation Modeling (SEM) using AMOS version 22 software. Based on the analysis that has been done, the results of entrepreneurship education have no significant effect on entrepreneurial intention, entrepreneurship education does not significantly influence self-efficacy, entrepreneurial motivation has a significant effect on self-efficacy, entrepreneurial motivation has a significant effect on entrepreneurial intention, self-efficacy has no significant effect towards entrepreneurial intentions, self-efficacy cannot mediate entrepreneurial education on entrepreneurial intentions, self-efficacy cannot mediate entrepreneurial motivation towards entrepreneurial intentions.