Background: Dry eye Disease (DED) is one of the most common conditions encountered in ophthalmology. DED is a multifactorial disease in the tear eyes and eye surface which results in instability of tear film, ocular discomfort and visual disturbances. DED symptoms include constant eye irritation, foreign body sensation and blurred vision. DED causes a negative impact on the patient's daily life and social function, making DED an important public health problem. One of the DED factors is the use of antidepressant drugs and anti-anxiety drugs that are used by depressed and anxious patients. Objective: The aim of this study was to identify Dry Eye Disease in depressed and anxious patients who used the antidepressant drugs and anti-anxiety drugs in RSJ Prof. dr. Soeroyo Magelang. Methods: This study used cross sectional method. The population in this study were patients in RSJ Prof. dr. Soeroyo Magelang who diagnosed as depressed and anxious patients with consumption antidepressant drugs and anti-anxiety drugs, included inclusion and exclusion criterias. 60 patients were collected, with each 30 patients is diagnosed a depressed and anxious. All patients were tested by Schirmer test to identify the Dry Eye Disease and classification of Dry eye Disease. Result: The results showed patients who treated by antidepressants and antianxiety has classification into Dry Eye disease with the higher used in Amitriptiline as antidepressant (p=0.034), Alprazolam, and Fluoxetine as antianxiety (p=0.040), which means the correlation between depression and anxiety can be found with Dry eye Disease. Conclusion: The Corellation between antidepressants and anti-anxiety can be found in Dry Eye Disease.