This study aims to analyze Capital (CAR), Bank Efficiency (BOPO), Liquidity (LDR), Inflation and SBI Interest Rate on Banking Profitability. Where this research is subject to all Conventional Banks listed on the IDX in the period 2012-2016. The number of samples in this study amounted to 160 data selected by purposive sampling method. The analysis tool used is SPSS version 21 and by using multiple linear regression methods. Based on the analysis that has been done, the first result is obtained, Capital (CAR) has a positive and not significant effect on profitability (ROA), Bank Efficiency (BOPO) has a negative and significant effect on profitability (ROA), Liquidity (LDR) has a positive and significant effect towards profitability (ROA), inflation has a negative effect and is not significant to profitability (ROA), and the SBI interest rate has a positive and insignificant effect on profitability.