Background: Patient Simulation that can play a real role or High Fidelity Simulation (HFS) has not been widely applied in Indonesia. Practice based simulation model (PBSM) is an alternative to HFS because it can affect critical thinking and performance skills. The purpose of this study was to analyze the influence of PBSM on critical thinking and psychomotor nursing students in the nursing skill laboratory. Methods: The study design used quantitative methods (Quasy Experiments), with the pretest-posttest approach with control group design. Data analysis using Wilcoxon and Mann Whitney. Results: PBSM has an effect on critical thinking and psychomtor (p) 0.001 <0.05, the ability to consciously think has a relatively limited capacity in the brain so it needs to be trained with various scientific approaches and PBSM is proven to effectively improve thinking and psychomotor critical. Conclusions: PBSM has the advantage of increasing student critical thinking and psychomotor, but further in-depth needs to be done regarding the PBSM method with more different measurement methods and techniques.