Background: Dental education is an integral part of education that consists of academic program and professional program which aims to create competent dentist graduates. The system that applied in the dental profession education which very complex is the reason for the high level of stress on students. Stress levels can affect physical and psychological conditions. One of the natural selfmanagement in reducing stress is coping strategies. This method is carried out intentionally or unintentionally by every individual who experiences stress. Research Objective: To find out the relationship between coping strategies and stress level of the students in Clerkship Program School of Dentistry, Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta. Research Method: The research design was an analytical observational with a cross-sectional approach. The sample was 87 students in Clerkship Program School of Dentistry, Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta with a stratified sampling technique. The research data were found from the filling of the stress level questionnaire of DASS (Depression Anxiety and Stress Scale) and the coping strategies questionnaire of Brief Cope. The data analysis used was Spearman correlation test. Result: The result showed that most of the student's stress level was very high and female students had a higher stress level than males. The relationship between coping strategies had N (r):0,361 and significance (p)<0.05, which means that there is a relationship between each variable and the relationship is weak. Conclusion: Based on the research result, it could be concluded that there was a significant relationship between coping strategies and stress level of the students in Clerkship Program School of Dentistry, Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta.