| dc.contributor.author | Setyawati, Ika | |
| dc.contributor.author | Mus, Rosdiana | |
| dc.contributor.author | Sadewa, Ahmad Hamim | |
| dc.contributor.author | Hastuti, Pramudji | |
| dc.contributor.author | Puspasari, Anggelia | |
| dc.contributor.author | Maharani, Citra | |
| dc.date.accessioned | 2020-05-26T03:53:12Z | |
| dc.date.available | 2020-05-26T03:53:12Z | |
| dc.date.issued | 2019-10-13 | |
| dc.identifier.issn | 1857-9655 | |
| dc.identifier.uri | https://www.id-press.eu/mjms/article/view/oamjms.2019.844 | |
| dc.identifier.uri | http://repository.umy.ac.id/handle/123456789/34095 | |
| dc.description.abstract | BACKGROUND: Metabolic syndrome (Met-S) that caused by heredity and Lipoprotein Lipase (LPL). LPL is involved in the metabolism of serum lipids. Variations in LPL alter enzyme activity, and the most common variations are LPL+ 495 T> G and LPL Pvu II C> T.
AIM: This study aimed to identify the role of LPL+ 495 T> G and LPL PvuII C> T gene variations in subjects with Met-S in Javanese ethnic based on age stratification.
METHODS: We recruited 160 participants of Javanese ethnicity consisting of 80 cases and 80 control subjects. Met-S was diagnosed according to the criteria of NCEP ATP III. Peripheral blood samples were collected to determine biochemical parameters. Screening for both polymorphisms was made by PCR-RFLP.
RESULTS: Results found that genotype and allele frequencies for LPL+ 495 T> G were not significantly different between Met-S and controls with and without age stratification. In LPL PvuII C> T based on age stratification, there were significant differences between TT vs CC, recessive and dominant models in Met-S and control. In the age group> 45 years CC genotypes and TC+ CC had increased risk of Met-S compared to TT genotypes. In summary, there was no significant association between LPL+ 495 T> G gene variation with Met-S.
CONCLUSION: In LPL PvuII gene variation, TC+ CC is the risk genotype of Met-S in the age group> 45 years. | en_US |
| dc.description.sponsorship | Dana Masyarakat (Damas) at 2018 number UPPM/362/M/05/04/05.18 and “Rekognisi Tugas Akhir” at 2019 Faculty of Medicine, Public Health, and Nursing, UGM, Indonesia | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | ID Design Press, Skopje Republic of Macedonia | en_US |
| dc.relation.ispartofseries | OAMJMS;Vol.7 No 21 (2019) | |
| dc.subject | Lipoprotein Lipase | en_US |
| dc.subject | LPL 495 T > G gene variation | en_US |
| dc.subject | LPL Pvu II gene variation | en_US |
| dc.subject | Metabolic syndrome | en_US |
| dc.title | Age Stratification in Genetic Variation of Lipoprotein Lipase in Metabolic Syndrome Javanese Ethnics of Indonesia | en_US |
| dc.type | Article | en_US |
