This study aims to analyze the Effect of Profitability, Firm Size, Liquidity, Asset Growth and Asset Structure on the Capital Structure of Manufacturing Companies Listed on the Indonesia Stock Exchange (BEI) in 2015-2018 both partially and simultaneously. In this study the samples obtained amounted to 274 manufacturing company data using purposive sampling that is based on certain criteria. The analytical tool used is SPSS. Based on the analysis there are three variables that are accepted and two variables that are rejected. The results of this study that Firm size has a positive and significant effect on capital structure, liquidity has a negative and significant effect on capital structure, Asset growth has a positive and significant effect, profitability has a positive and significant effect on capital structure, and the asset structure has a negative and no significant effect on structure Capital.