Background: “To err is human” stated by Institute of Medicine showing the abundance of medication prescription errors which compromises patient safety and exaggerates health care cost. These errors could be prevented by the use of health information technology such as Electronic Medical Records, that can streamline, simplify, and unify patient care. Aim: The aim of this study is to determine the use, types and development of CPOE and CDSS in Hospital Information Systems Method: Systematic review, researchers arranged the keywords, then conducted a search with 4 databases (PubMed, ScienceDirect, EBSCO, dan ProQuest) from that databases. The screening was conducted starting from the title, then based on the abstract, then finally the full paper. Researcher also looked at whether the journal was Scopus-indexed or not, then 40 journals were reviewed. Result: 40 journals that were stated to be included in this analysis, grouped by study site, whether one-center or multi-center. 26 journals are one-center. From 40 journals, only 2 types of CPOE that are shared by different hospitals and only 3 types of CDSS that are shared by different hospitals. Both CPOE and CDSS are mostly a commercial program. Conclusion: This study found that the hospitals already used the CPOE and CDSS, but in different types of that, most of the system is commercially purchased, and there is no explanation of the presence of a trusted institution that controls the production and the development of CPOE and CDSS.