This research aims to analyze the influence of work family conflict and family work conflict toward job stress and work satisfaction. The subject of this research is nurses of PKU Muhammadiyah Yogyakarta Hospital. This research used purposive sampling technique by criteria of female nurses who are married and have children. Survey method as the method of data collection by spereading questionnaire to 185 respondents Data analysis tools used in this research is Structural Equation Modeling (SEM). The result of this research shows that; 1) work family conflict does not significantly influence to job stress, 2) family work conflict does not significantly to job stress, 3) job stress has negative and not significantly to work satisfaction, 4) work family conflict has positive and significantly to work satisfaction 5) family work conflict has positive significantly to work satisfaction.