This aim of this research is to analyze the influence of profitability, growth of asset, firm of size, asset structure towards the capital structure. The object of this research is a manufacturing company in Indonesia in stock exchange from 2010-2012. The sampling technique use the purposive sampling method, in order to obtained 178 data. The types of collecting data use the secondary data that is the documentation method from Indonesia stock exchange and use a model of multiple linear regression analysis. The result of this analysis is the Profitability of variable affect positively and significant on the Capital Structure, while The Growth of Asset and Firm of Size affect negatively and not significant, Asset Structure and Liquidity affect negatively and significant on the Capital Structure. The advice for the next research is to add other internal and external variables that has not been put in the research as Institutional Ownership, Financial Flexibility, The Stability of Sales, Business Risk, Management Attitude, Internal Condition of Company, expand the sample and research population on all types of companies.