This research aims to determine whether the independent variables profitability, firm size, business risk, asset structure, and growth companies to the dependent variable, capital structure. This study using secondary data, that was the annual financial report of manufacture companies listed on the Bursa Efek Indonesia (BEI) during the period 2011-2013. This study uses purposive sampling method and data analysis used are multiple regression analysis. The result of this research that variables profitability, business size, business risk, asset structure, and growth companies have significant effect on the dependent variable simultaneously. Partially, it can be seen that the variables firm size and asset structure have a positive and significant effect on the capital structure, profitability and business risk have a negative and significant effect on the capital structure, and the growth companies has positive and not significant on the capital structure.