This study aimed to analyze the effect of capital adequacy ratio (CAR), credit, and interest rates on profitability (return on assets-ROA) banking companies listed PD BPR Karya Remaja. This research is classified research causative population banking companies listed in PD BPR Karya Remaja. While this sample was determined by purposive sampling method so obtained 60 samples of 15 banking companies in the observation period (2012-2015). The data used is secondary data obtained from PD BPR Karya Remaja Condensed Financial Statement.The analytical method used is regression analysis using Eviews. The results showed that the CAR significant effect on ROA in PD BPR Karya Remaja in Indramayu, Credit significant effect on ROA in PD BPR Karya Remaja, interest rates not significant effect on ROA in PD PBR Karya Remaja in Indramayu.