Congestive Heart Failure (CHF) is a common disorder resulting in pulmonary vascular congestion and reduce cardiac output. Since 2003, the number of patients with hospitalisasi heart failure diagnosis increases ranging between 1200-1300 patients per year. The disease often causes complications so that a given treatment will become more complex and risky going on Drug Related Problems (DRPs). DRPs is an event or situation where drug therapy is potentially or explicitly can influence the outcome of therapy is desirable. The purpose of this research is to know the description of DRPs in Congestive Heart Failure patients therapy (CHF) who underwent hospitalization in RS PKU Muhammadiyah Yogyakarta. The research of non-experimental descriptive in nature. Data taken as a retrospective medical record entry of 16 patients of Congestive Heart Failure at the hospital that PKU Yogyakarta meets the criteria of inclusion in the month of January-June 2015. Analysis of DRPs that potentially occur using the analysis of the study of literature in the form of ACCF/AHA : Guideline for the Management of Heart Failure: update 2013, Standar Pelayanan Medik (SPM) Congestive Heart Failure di RS PKU Muhammadiyah Yogyakarta, Pedoman Tata Laksana Gagal Jantung Edisi Pertama (PERKI, 2015), dan Drug Interaction Facts. The results showed that DRPs that occur on a potential treatment congestive heart patients in Inpatient Hospital Installation PKU Muhammadiyah Yogyakarta as many as 20 events from 16 patients with category drug interactions as much as 11 events (55%), the selection of the remedy is not appropriate as much of the 7 events (35%), inappropriate doses as much as category 1 events (5%) and drug adverse reaction category as much as 1 events (5%).