Infectious diseases belong to the top ten diseases that attack humans. Infectious disease caused by bacteria can be cured with antibiotic. Antibiotic is categorized as hard drug that only can be obtained with doctor’s prescription. Most of the society uses antibiotics to solve infection problems caused by virus and there are still many people who buy antibiotics without a doctor’s prescription. It can causes the bacteria become resistant toward antibiotics. Data of antibiotic use in Yogyakarta that is not rational to treat diarrhea or other infectious diseases are of 58%. If the antibiotics giving that is not appropriate to children under five, it will cause bacteria resistant toward disease caused by bacteria. Therefore, it needs to find out how the perception of parents toward the use of antibiotics to child under five is so that there will be no mistakes in the taking of antibiotic. The objective of this research is to find of the perception of the parents toward the use of antibiotics for children under five. The research was a qualitative in nature with phenomenological approach. The number of the informants in the research was 17 people i.e. Mothers having children under five. The data collecting technique was conducted with in-depth interviews and focus group discussion technique. The data analysis in the research was using software open code 4:02. The research results showed that the perception of the parents toward the use of antibiotic is categorized as good. The parents regarded that antibiotic was used to cure diseases caused by bacteria. Antibiotic could only be obtained through doctor’s prescription and taking should be appropriate with the prescription given. However, there ware factors that influence the attitude of the parents in giving antibiotic to their children, so that the taking became inappropriate. It needed to do research related to attitude of taking antibiotic and the factors that influence it.