The aims of this research were to determine the influence of asset structure, institutional ownership, profitability and firm size on financing decision at manufacturing company registered on the Indonesia Stock Exchange. This research was classified as causative study. The population of this research was manufacturing company registered on the Stock Exchange in 2012 until 2014. Total sample were 219 samples. The data collected using purposive sampling method. The data was obtained from the Indonesian Capital Market Directory (ICMD) and www.idx.co.id. Data analysis techniques was used as analysis double regression technique. The result of research show that asset structure hasn’t effect on financing decision. Institutional ownership and profitability has negative effect on financing decision. Firm size has positive effect on financing decision. Keywords: Asset Structure, Institutional Ownership, Profitability, Firm Size, Financing Decision.