This research was to test empirically the effects of the Government's internal control System, organizational culture, organizational commitment as well as the application of the principles of Good Corporate Governance against the Managerial Performance of hospitals. Methods in this study used a survey method, a device used in data retrieval using the questionnaire. The population in this research the whole hospital in pemalang, the sample in this study using a purposive sampling method with certain criteria which totaled 144 respondents after the data processed as many as 32 outliers occur so that a total of 112 respondents only samples that can be used. In this research analysis tools using multiple linear regression analysis. The results of this research show that: (1) the system of internal control of the positive effect of the Government's response to the Managerial Performance; (2) organizational culture does not have an effect on Managerial Performance; (3) a positive effect against organizational commitment to performance menejerial; (4) Principles of Good Corporate Governance positive effect on Managerial Performance. It concluded that improvements in the implementation of the internal control system of government the better managerial performance, the lack of organizational culture that are applied in the organization then knerja managerial going to get worse, the improving organizational commitment every employee will bring managerial performance is also getting better and good application of the principle good corporate governance, the better managerial performance.