LOZONGES FORMULATION FROM EXTRACT MIRACLE FRUIT WITH FREEZE DRYER METHODE: IMPROVEMENT HERBAL DOSAGE FROM ADDICTION SMOKER THERAPY
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Smoking is widely has become one of the biggest causes of death in the world. The World Health Organization (World Health Organization or WHO) declared a billion people will die from tobacco in each country. The number of smokers worldwide is now at 1.2 billion people and 800 million of them axe in developing countries. Indonesia is the third country with the largest number of smokers in the world after China and India. Several efforts have been taken by the government to reduce tobacco consumption such as increased cigarette taxes, as well as the application of non-smoking areas, but it has not had a significant impact in reducing tobacco consumption was proven that the high number of tobacco consumption in Indonesia. Efforts to prevent and control tobacco consumption, is the best option in addition to the increase in taxes on cigarettes, advertising bans as a whole, as well as the application of non-smoking areas, but many smokers who claim it is difficult to quit smoking due to the effects of cigarette addiction is very strong. Several therapies have been offered both medical and non-medical to help smokers quit smoking. The high cost of medical treatment incurred by patients for smoking cessation therapy being one of the obstacles in the control of tobacco consumption. Traditional drug development has started in Indonesia in an attempt to obtain a safer drug therapy with minimal side effects. One of the plants has efficacy as a drug to treat addiction from cigarettes are miracle fruit (Synsepalumdulcificum). Potential miracle fruit plant in Indonesia to serve as a traditional medicine against various diseases is enormous. This is due to the chemical content of the miracle fruit (Synscpalumdulcificum) is efficacious as a medicine miraculin. In Indonesia, the use of miracle fruit (Synsepalumdulcificum) for therapeutic treatment is still very limited. While in the United States and China miracle fruit plants have been widely used in the treatment of therapy specifically for the treatment of cancer and diabetes. The FDA has approved the miracle fruit as an alternative sweetener for diabetics. In addition to cancer therapy and diabetes, miracle fruit (Synsepalumdulciticum) is also believed to be used to overcome the effects of cigarette addiction. The method used in the manufacture of lozenges is a method of freeze dryer. miracle fruitextraxion by maceration method, then the results of using the tool diserbuk extract spray dryer. The results obtained powder then formulated into lozenges. Testing was conducted on the test of time dissolve tablets in the mouth, weight uniformity, and hardness, friability, granule flow properties, tapp density. From the results obtained showed that the loxengesmiracle fruit extract has met several test requirements include: test weight uniformity, tablet hardness, friability tablet, soluble tablet time trial, and the flow rate of granules and granule silent corner. so that the product is stable farmasetis.