In 2010, there is an increase in the age of starting smoking from all ages, and at the age of 15-19 years the number of smokers in Indonesia dominate as much as 43.3%. In yogyakarta shows active smokers was 21.6% of high school students (Quite Tobacco Survey of Indonesia, 2011). Some of the biggest causes of death caused by smoking include heart disease, chronic obstructive pulmonary disease, lung cancer, and respiratory infections (American Cancer Society, 2010). Therefore, we need a method that can reduce the increased number of active smokers each year by disease picture printed-cigarette packageof active smokers in cigarette consumption. This study uses survey method. In this study, whe observed theeffect of disease picture printed-cigarette package in active smokersof high school students in the city of Yogyakarta. The samples in this study were all male students active smokers in high school in the city of Yogyakarta until the sample size is met. Primary data collection in this study was a questionnaire. This research is quantitative. Time and Place of Execution of this study was conducted in June- September at SMA Muhammadiyah in Yogyakarta, namely SMA Muhammadiyah 1, 2, 3, 6 Yogyakarta. The results stated that the age of the student smokers consumed an average of less than 10 cigarettes per day. Almost all smokers at student ages had read the impact of smoking and most of them are worried about the impact of the smoking habit. The most effective method to reduce smoking by the respondent is using disease picture printed-cigarette package that are considered the most effective way to reduce or quit smoking is a picture of lung cancer, oral cancer and impotence. Most smokers student worried about the dangers of smoking to health if cigarette packaging disease image of active smoker is circulating in Indonesia, and they can not tell whether to buy it or not, but the cigarette pack that display this disease made them think to quit smoking and if the packaging is really outstanding in Indonesia, most student smokers will reduce the intensity of smoking. With the obtained results, the researchers suggest for other research be done in a larger scope, which can be done in various major cities in Indonesia so that research results can be used as a reference for the government to apply disease picture printed-cigarette packagecancirculate in Indonesia.