This research aimed to know the dominant sectors in Kupang regency. This research used Shift Share, Location Quotien (LQ), Growth Ratio Model, Typologi Klassen and SWOT analysis approaches, by comparing Gross Regional Domestic Product based on the Constant Prices in 2010 and Gross Regional Domestic Product based on Constant Prices in East Nusa Tenggara in 2010. The result of Shift Share research analysis showed the potential sectors in East Nusa Tenggara were the large trading and retail sectors, such as the reparation of cars and motorcycles, transportation, and warehousing, because they had the biggest value in PDRB constribution in East Nusa Tenggara. They also had revenue growth which faster than the same factors at the provincial level in East Nusa Tenggara. The result of Location Quotien (LQ) showed the six sectors which were included as the basic sectors,namely agriculture, forestry and fisheries, mining and quarrying, processing industries, construction, large trade and retail such as the reparation of cars and motorcycles, transportation, and warehousing. The result of Typologi klassen analysis were the agriculture sector, forestry and fisheries sector, processing industries sector, water supply sector, waste management, waste and recycling, information and communications, and enterprise services sector. The result of MRP research analysis showed the electricity and gas sector, procurement sector, financial and insurance services sector, and the goverment administration, defense and mandatory social security services sector. While based on the SWOT analysis, the development policy strategy of the leading sector which needs to be taken was the improvement of the regional economy through the potential of the base sector so it could improve the service quality of health, education, and other basic social services. It could also improve the quality and quantity of public infrastructure facilities and improve the economic competitiveness between district and followed by the improvement between provinces.