This study aims to analyze the influence of system quality, quality of information, and service quality to the level of satisfaction of users of regional management information system at Mukomuko district government, Bengkulu province. The subject in this study was users of regional management of information system specially at Mukomuko district government. In this study, the number of qualified samples are 40 respondents were selected using purposive sampling. Analysis tool used in this study is the Multiple Linear Regression. Based on the analysis that have been made the result are the system quality, quality of information, and service quality bring significant and positive impact on user satisfaction partially and simultaneously.