Learning outcomes achieved by learners are influenced by the existing learning activities in the classroom or in the laboratory clinics (skills lab). Laboratory learning process or lab skills must meet the established quality standards, if skill lab activities are not in accordance with curriculum standards it will affect the learning outcomes and not achievement of some learning objectives. This study aims to know the relationship of learning quality of lab skill with OSCE result on Nursing Program students of Faculty of Medicine and Health Sciences Muhammadiyah University of Yogyakarta. This research type is non experiment research with quantitative method and using descriptive correlational design. The approach used is cross sectional approach. Respondents in this study amounted to 90 people using quota sampling technique. Data analysis using chi square. There is no correlation between learning quality of lab skill with OSCE result with p value 0,66. There is no correlation between learning quality of lab skill with OSCE result due to other factors.