Swelling ratio is the ability of the scaffold to absorb the liquid while maintaining its balance at the same time. Therefore, the scaffold does not change in shape. Platelet-rich plasma (PRP) is an autologous concentration of platelets which contain growth factors. PRP has an ability to incorporate with the scaffold for bone tissue engineering. Aimed of this study is to define the influence of incorporated PRP to synthetic coral scaffold to the swelling profile. The design of this study is experimental laboratory. Platelet-rich plasma was prepared by a double-spinning methode by Tabata. The blood sample was taken from lateral tail vein of wistar rats (Rattus norvegicus). The synthetic coral scaffolds prepared from gelatin and calcium carbonate (CaCO3). Six synthetic coral scaffolds were divided into two groups. First is PRP incorporation group (n=3) and the second is synthetic coral scaffolds without PRP as the control (n=3). The synthetic coral scaffold dipped in 70μl of PRP for 15 minutes. Then the scaffolds were placed in the phosphate buffer saline and incubated for 48h at 37℃. The weight of the scaffold at swelling condition was measured every 30 minutes. The data were analyzed by Independent T test and the result showed no significant different between two groups in this research. However, the graphic showed that incorporated PRP synthetic coral scaffold had higher swelling ratio than non-incorporated PRP at the initial time. According to this study, it can be concluded that the incorporation of PRP in synthetic coral scaffold has an affect to the swelling profile.