Degradation of scaffold is an important factor in the tissue engineering to form a newly tissue. Platelet-rich plasma (PRP) is one of bloods component which nourished by growth factor. Hydrogel scaffold degradation process which incorporated with PRP at the same time also created growth factor that is made by PRP. Aimed of this study is to develop the respons of PRP to the degradation profile on CaCO3 scaffold. Platelet-rich plasma preparation was use the method from Tabata by double-spinning method. Blood was taken from lateral vein of wistar rats (rattus norvegicus). Six synthetic coral scaffolds were divided into two groups. First is PRP incorporation group (n=3) and the second is synthetic coral scaffolds without PRP as the control (n=3). Synthetic coral scaffolds dipped into 75l of PRP for 15minutes. Incorporated and non-incorporated PRP on both sides were placed in 1 ml of PBS then incubated for 1 hours at 370C. At different time intervals 1, 3, 6, 24, 48 and 96 hours the solution supernatant was removed and replaced with the same volume of fresh PBS solution. After 96 hours the solutions were changed with HCl 1N for accelerate solutions the incubated at same time intervals like PBS. The Independent T test showed no significant different on both incorporated or non-incorporated PRP. Meanwhile, based on the average graphic percentage a degradation showed movement on scaffolds curves without non-incorporated PRP was lesser than incorporated PRP. The conclusion, this study explains the influences of incorporated PRP with CaCO3 scaffolds on degradation profile.