Background: Kidney failure is a clinical condition characterized by an irreversible decrease in kidney function, to a degree requiring permanent renal replacement therapy, in the form of dialysis or renal transplantation. Blood washing (hemodialysis, often abbreviated as HD) is one of the therapies in patients with renal failure in which case the blood washing function should be done by the kidneys replaced by machines to remove certain metabolic or toxic remnants from the human blood circulation such as water, sodium, potassium, Hydrogen, urea, creatinine, uric acid and other substances. Ureum and creatinine are chemical compounds that indicate normal kidney function. Aim: Determine the differences between blood pressure pre-post hemodialysis and creatinine level pre-post hemodialysis Methods: This research was conducted in March 2016-May 2017 by using analytic observational design with cross sectional approach. Data analysis was done using paired sample t test. Result: This study involved 160 patients with chronic renal failure in RSUP Dr. Sardjito Yogyakarta. Patients with decreased blood pressure in accordance with JNC 8 were 56 people. All patients had decreased creatinine levels but were still relatively high. Conclusion: There is a difference between high blood pressure pre-post hemodialysis with pre-post hemodialysis creatinine levels