Background: Circumcision is a small operation act performed by removing the foreskin to uncover the head of the penis permanently. Circumcision will inflict pain due to the wounded skin of the penis. The pain that re-emerges after the anesthesia effect wears off could be resolved by the provision of analgesic medicine, one of which is ibuprofen. However, children sometimes could not consume per oral medicines. One of the alternatives is per rectum or rectal suppository. This research is necessary to figure out the effect of ibuprofen dosage form towards its effectivity in relieving pain. Method: Quasi experiment was performed to 14 children of 7-14 years old who were divided into 2 treatment groups. Pain evaluation was conducted in 60 minutes and 120 minutes after anesthesia provision by using Visual Analogue Scale. The data analysis used statistical Independent Sample t Test to discover the effect of dosage form to the pain rate on VAS. Result: Ibuprofen provision has VAS value of minimum 2, maximum 4, and average 2,67. While suppositoria ibuprofen has VAS value of minimum 1, maximum 4, and average 2,50. Based on the observation, it was found that the average VAS value of oral dosage form provision is higher than the suppositora dosage form provision with the result of Independent Sample t Test is 0,775 (P value >0,05). Conclusion: Both the provision of oral ibuprofen and suppositora ibuprofen on the patients post-circumcision as the anti-pain agent shows insignificant differences in its result. The effect of gene variation, effect of environment and the effect of placebo become the respondents’ responses most dominant factors toward ibuprofen therapy. Furthermore, during therapy, if the dosage given was compatible to the age, weight, and dosage form, it will result to an insignificantly different result of the therapy effect.