Coronary heart disease with dyslipidemia risk factor is the most common cause of mortality in the world. One of the treatments is to deal with this disease was throught percutaneous coronary intervention (PCI). This treatment needed strict supervision such as lifestyle intervention, doing routine control and providing pharmacological intervention to avoid restenosis and ADR. Restenosis and ADR had been an adverse responsed of patients that would influence the quality of life. Therefore, this study aimed to determine the patients responsed to PCI therapy included the result of checked up lipide profil, ADR, and symptoms of restenosis. The research wa a non-experimental research with descriptive analysis. Data was collected retrospectively from Januari to February 2018 in RSUP Dr.Sardjito Hospital from inpatients medical records. Data collection techniques in the form of total sampling, obtained 44 samples according to inclusion criteria. Patients responsed was analyzed by identification of lipid profile examination results, ADR and symptoms of restenosis. The results showed that responses of coronary heart disease patient with dyslipidemia risk factor after PCI including increased in the total cholesterol (65,52%), increased of LDL (58,54%), increased of triglyceride (69,23%) and decreased of HDL (88,00%), adverse drug reaction (2,27%), indicated restenosis symptoms (52%), and no indicated of restenosis symptoms (48%).