The off-label drug use is drug used not in accordance with the information listed on the label or product leaflet. There were found evidences and reports on the off-label drug use especially in the category of indication. Pregnant woman are special population that need attention related to the drug administration. This study aims to discover the representation of off-label indication in pregnant woman of Rumah Sakit Jogja. This study conducted using descriptive observational design with cross-sectional approach. The sampling in this study used retrospective method on medical records of pregnant woman of Rumah Sakit Jogja. The medical record samples of 298 were taken using systematic random sampling technique from January to December 2016. The samples were then analyzed based on the information of drugs listed on the PIO Nas [National Drug Information Center] and related journals. The result showed that there were 2075 prescribed drugs in which there were 98 prescribed drugs (4,72%) categorized as off-label drug indication. The off-label drug indication use included misoprostol 79 (3,81%), dexamethasone 16 prescribed (0,77%), and ondansetron 3 prescribed (0,14%).