Background: Platelet-rich Plasma (PRP) is defined as concentrated platelet that consists of a great amount of growth factors. PRP has important role in bone recovery process. Platelet-rich Fibrin is the development of concentrated platelet that does not use anti coagulant. PRF is also called as leukocyte-PRF since it has anticipation character in tissue regeneration and wound recovery. PRP and PRF can be incorporated using scaffolding in engineering bone tissue. Scaffolding materials are insoluble or degradation in order that the release of growth factors in accord with bone tissue development process. Research objective: The research aimed at learning the difference of degradation profile in the scaffolding incorporated with PRP, PRF, and without incorporation. Research Method: The research design is clinical laboratory research using pre and post test design. The subject of the research is artificial coral scaffolding. PRP was made using Matsui-Tabata method. PRF was made using a method by Choukron et all. The blood used was human blood. 9 scaffoldings were divided into 3 groups; scaffolding with PRP incorporation, PRF incorporation, and without incorporation. The artificial coral scaffolding was soaked in PBS and was incubated with the temperature of 37o. Degradation profile was measured after 1, 3, 6, 24, 48, 72, and 96 hours. PBS was then replaced with HC1 1N and was incubated with the temperature of 37o . Degradation profile was measured again after 1, 3, 6, 24, 48, 72, 96 hours until the scaffolding was degraded until it ran out. Research Result: The data of the research were analyzed using One Way Anova and continued with Post Hoc test using Tukey. The result of One Way Anova indicated that there was significant difference (p<0.05) in the soaking period of 1, 3, 6, 24, 48, 72, 96 hours and 1 hour period of HC1 soaking. Conclusion: Based on the research, it is concluded that there was degradation difference between scaffolding with PRP incorporation, PRF incorporation, and without incorporation. PRP addition could strengthen the scaffolding structure with the development of fibrin network so that it could slow down the degradation process.