Background: OSCE (Objective Structured Clinical Examination) is one of the performance evaluation method that can recognise the ability of the students to implement their knowledge. The simulation condition in OSCE is created like in a world of work that requires the students to think fast under pressure. It is the reason why the students often experience anxiety before, during, and after OSCE. The anxiety can influence the process of thinking, perceiving, and studying. Research Objective: To find out the relationship between anxiety level and OSCE performance of the students in Dentistry Study Program, Faculty of Medicine and Health Science UMY. Research Method: The research design was analytical observational with cross sectional approach. The sample was 89 students in Dentistry Study Program, Faculty of Medicine and Health Science UMY, with proportionate stratified sample collecting technique. The research data were found from the filling of anxiety questionnaire of BAI (Beck Anxiety Inventory) and the data of the students performance score on OSCE from the 4th,10th,16th and 22nd blocks. Research Result: The data analysis used Somers’d correlation test with value of r:0,006, p > 0.05. Based on the research result, it could be concluded that there was no significant relationship between anxiety level and OSCE performance of the students in PSPDG FKIK UMY.